Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 12 Researches
8
USERS' SCORE
Good
Based on 10 Reviews
8.5
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
1,360 mcg DFE** (800 mcg folic acid)
340%
Vitamin B-12 (as Cyanocobalamin)
25 mcg
1042%
Top Medical Research Studies
8
We explored the potential of folate as a diagnostic aid for brain tumors, specifically targeting gliomas—some of the most challenging brain cancers. A key part of our approach involved developing a micellar delivery system that could be given through the nose. This method is less invasive and may provide a more effective way to reach brain tumors.
In our research, we took advantage of the fact that folate receptors are overexpressed in brain tumors, making them an excellent target for diagnosis. We synthesized a folate-conjugated agent, labeled it with technetium (Tc), and encapsulated it within micelles for improved delivery.
Testing revealed that these micelles had a safe profile for nasal administration in rats. In mice, the micelles demonstrated significantly better uptake in the brain compared to a standard folate solution. Imaging studies using specialized techniques showed that these micelles could effectively accumulate in brain tissue.
The findings suggest that this innovative formulation could not only help detect brain tumors but might also be applicable to other cancers that express folate receptors, such as those in the cervical, breast, and lung areas. Overall, we believe our approach has the potential to enhance cancer diagnosis in a fast, accurate, and non-invasive manner.
In our research, we took advantage of the fact that folate receptors are overexpressed in brain tumors, making them an excellent target for diagnosis. We synthesized a folate-conjugated agent, labeled it with technetium (Tc), and encapsulated it within micelles for improved delivery.
Testing revealed that these micelles had a safe profile for nasal administration in rats. In mice, the micelles demonstrated significantly better uptake in the brain compared to a standard folate solution. Imaging studies using specialized techniques showed that these micelles could effectively accumulate in brain tissue.
The findings suggest that this innovative formulation could not only help detect brain tumors but might also be applicable to other cancers that express folate receptors, such as those in the cervical, breast, and lung areas. Overall, we believe our approach has the potential to enhance cancer diagnosis in a fast, accurate, and non-invasive manner.
Read More
9.5
We explored the potential of folic acid-conjugated nanoparticles to target glioma stem cells (GSCs) and suppress tumor growth. By delivering small-interfering RNA (siRNA) against CD146, a protein linked to tumor growth, we observed significant results in mouse models.
The study showed that these nanoparticles effectively accumulated in tumor sites and significantly reduced tumor growth. In some cases, complete tumor removal was noted. This research suggests a promising avenue for gene therapy in treating malignant gliomas.
The study showed that these nanoparticles effectively accumulated in tumor sites and significantly reduced tumor growth. In some cases, complete tumor removal was noted. This research suggests a promising avenue for gene therapy in treating malignant gliomas.
Read More
9
Folic acid-modified exosomes boost treatment
We explored a new approach to deliver temozolomide, a drug used for glioma, by using exosomes modified with folic acid. This method aimed to improve drug targeting and reduce side effects.
Our results showed that folic acid-modified exosomes delivered temozolomide more effectively to glioma cells. In tests, this approach significantly reduced tumor growth and improved survival rates in mice compared to traditional methods.
While the study suggests this could be a promising treatment option, we found no direct evidence that folic acid alone significantly impacts brain tumors.
Our results showed that folic acid-modified exosomes delivered temozolomide more effectively to glioma cells. In tests, this approach significantly reduced tumor growth and improved survival rates in mice compared to traditional methods.
While the study suggests this could be a promising treatment option, we found no direct evidence that folic acid alone significantly impacts brain tumors.
Read More
Most Useful Reviews
9
Essential for development
8 people found this helpful
The folic acid dosage is very good. I began taking it in hopes of getting pregnant, and the results were swift, as I conceived in nearly two months. Before taking the pills, it did not work for over seven months. During pregnancy, folic acid is crucial for the development of the child, especially the brain and spinal cord. A deficiency can lead to severe consequences, including potential psychoses or mental retardation in the child.
Read More
9
Vital for fetal health
6 people found this helpful
Folic acid, part of the B-vitamin group, is crucial for DNA synthesis and cellular function. In early pregnancy, the fetus's organs, including the brain, develop quickly. Any defects during this critical period may lead to severe disabilities or death. Folic acid effectively reduces the risk of neural tube defects, making it essential for every woman, especially those who may become pregnant.
Read More
9
Supports nervous system
4 people found this helpful
I took folic acid (B9) for my pregnant girlfriend as prescribed by her gynaecologist to ensure the child's brain, heart, and genitourinary system develop normally. I highly recommend it for expectant mothers!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 12 Researches
8
- All Researches
9.5
We explored the potential of folic acid-conjugated nanoparticles to target glioma stem cells (GSCs) and suppress tumor growth. By delivering small-interfering RNA (siRNA) against CD146, a protein linked to tumor growth, we observed significant results in mouse models.
The study showed that these nanoparticles effectively accumulated in tumor sites and significantly reduced tumor growth. In some cases, complete tumor removal was noted. This research suggests a promising avenue for gene therapy in treating malignant gliomas.
The study showed that these nanoparticles effectively accumulated in tumor sites and significantly reduced tumor growth. In some cases, complete tumor removal was noted. This research suggests a promising avenue for gene therapy in treating malignant gliomas.
Read More
9
We explored an innovative treatment approach for glioblastoma multiforme by combining temozolomide and quercetin with folic acid-conjugated exosomes. The study showed that these exosomes enhanced drug delivery and penetration through the blood-brain barrier.
Our results indicated increased toxicity in brain tumor cells and a significant reduction in tumor size, indicating that this combination strategy could improve treatment outcomes. Through various experiments, we observed that folic acid's role in exosome uptake led to higher apoptosis rates in tumor cells, making this approach a promising avenue for glioblastoma therapy.
Our results indicated increased toxicity in brain tumor cells and a significant reduction in tumor size, indicating that this combination strategy could improve treatment outcomes. Through various experiments, we observed that folic acid's role in exosome uptake led to higher apoptosis rates in tumor cells, making this approach a promising avenue for glioblastoma therapy.
Read More
9
Folic acid-modified exosomes boost treatment
We explored a new approach to deliver temozolomide, a drug used for glioma, by using exosomes modified with folic acid. This method aimed to improve drug targeting and reduce side effects.
Our results showed that folic acid-modified exosomes delivered temozolomide more effectively to glioma cells. In tests, this approach significantly reduced tumor growth and improved survival rates in mice compared to traditional methods.
While the study suggests this could be a promising treatment option, we found no direct evidence that folic acid alone significantly impacts brain tumors.
Our results showed that folic acid-modified exosomes delivered temozolomide more effectively to glioma cells. In tests, this approach significantly reduced tumor growth and improved survival rates in mice compared to traditional methods.
While the study suggests this could be a promising treatment option, we found no direct evidence that folic acid alone significantly impacts brain tumors.
Read More
We explored how a folate analogue, [F]FOL, can be used for imaging brain tumors like gliomas. In our study, rats with gliomas were injected with the folate compound, which helps visualize areas with high levels of folate receptors (FRs) that are often found in tumors.
Through various imaging techniques, we were able to see that [F]FOL accrued significantly in glioma tissues. This suggests a direct relationship between the presence of FRs and the uptake of our imaging agent. Additionally, we examined human glioblastoma samples, confirming similar high FR expression.
Our findings not only highlight the potential of [F]FOL in enhancing the detection of gliomas but also pave the way for developing targeted therapies using folate. Overall, while our study showcases exciting possibilities for using folate in glioma imaging and treatment, specific effects of folate treatment alone weren't directly assessed.
Through various imaging techniques, we were able to see that [F]FOL accrued significantly in glioma tissues. This suggests a direct relationship between the presence of FRs and the uptake of our imaging agent. Additionally, we examined human glioblastoma samples, confirming similar high FR expression.
Our findings not only highlight the potential of [F]FOL in enhancing the detection of gliomas but also pave the way for developing targeted therapies using folate. Overall, while our study showcases exciting possibilities for using folate in glioma imaging and treatment, specific effects of folate treatment alone weren't directly assessed.
Read More
9
Folate-targeted nanoparticle effectiveness
We set out to explore how folate-targeted Erlotinib-loaded human serum albumin nanoparticles might impact brain tumors, specifically glioblastomas. Our research used both laboratory cell lines and a live rat model to examine the effectiveness of this treatment. The nanoparticles we developed, measuring around 135 nanometers in size, were designed to improve the delivery of Erlotinib, a drug known for its potential against certain tumors.
In laboratory tests, we observed that these folate-targeted nanoparticles showed a significantly lower concentration needed to inhibit cell growth compared to the free Erlotinib. For example, within 72 hours of treatment, the nanoparticles had an IC value of about 52.18 micrograms per milliliter for U87MG cells, while free Erlotinib required nearly double that amount.
Further investigations revealed that these nanoparticles also enhanced the rate of apoptosis, or programmed cell death, which is crucial for effectively shrinking tumors. In the rat model, we noted a remarkable reduction in tumor size—from nearly 87 mm to just over 1 mm after consistent treatment with the nanoparticles. Additionally, we found that the survival rate of these rats extended beyond 100 days, outperforming the control group.
Overall, this study strongly suggests that folate-targeted Erlotinib nanoparticles can effectively reduce tumor size and improve survival in a glioblastoma model, highlighting the potential role of folate in targeted cancer therapy.
In laboratory tests, we observed that these folate-targeted nanoparticles showed a significantly lower concentration needed to inhibit cell growth compared to the free Erlotinib. For example, within 72 hours of treatment, the nanoparticles had an IC value of about 52.18 micrograms per milliliter for U87MG cells, while free Erlotinib required nearly double that amount.
Further investigations revealed that these nanoparticles also enhanced the rate of apoptosis, or programmed cell death, which is crucial for effectively shrinking tumors. In the rat model, we noted a remarkable reduction in tumor size—from nearly 87 mm to just over 1 mm after consistent treatment with the nanoparticles. Additionally, we found that the survival rate of these rats extended beyond 100 days, outperforming the control group.
Overall, this study strongly suggests that folate-targeted Erlotinib nanoparticles can effectively reduce tumor size and improve survival in a glioblastoma model, highlighting the potential role of folate in targeted cancer therapy.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Essential for development
8 people found this helpful
The folic acid dosage is very good. I began taking it in hopes of getting pregnant, and the results were swift, as I conceived in nearly two months. Before taking the pills, it did not work for over seven months. During pregnancy, folic acid is crucial for the development of the child, especially the brain and spinal cord. A deficiency can lead to severe consequences, including potential psychoses or mental retardation in the child.
Read More
9
Vital for fetal health
6 people found this helpful
Folic acid, part of the B-vitamin group, is crucial for DNA synthesis and cellular function. In early pregnancy, the fetus's organs, including the brain, develop quickly. Any defects during this critical period may lead to severe disabilities or death. Folic acid effectively reduces the risk of neural tube defects, making it essential for every woman, especially those who may become pregnant.
Read More
9
Supports nervous system
4 people found this helpful
I took folic acid (B9) for my pregnant girlfriend as prescribed by her gynaecologist to ensure the child's brain, heart, and genitourinary system develop normally. I highly recommend it for expectant mothers!
Read More
9
Prevents brain cancer
Folic acid restores immunity and supports heart function; it’s vital for expectant mothers and aids in cancer prevention while enhancing brain health. It plays a significant role in egg maturation, normalising the menstrual cycle, and fetal development. I recommend consuming 400-800 mcg daily.
Read More
9
Increased energy
Great quality with top-notch ingredients! It's an easy-to-swallow size, and I feel it’s beneficial for my brain. I’ve noticed increased energy levels, improved potency, and a positive digestive response. It’s an excellent product from Iherb, and I will definitely purchase it again.
Read More
Frequently Asked Questions
9
Essential for development
8 people found this helpful
The folic acid dosage is very good. I began taking it in hopes of getting pregnant, and the results were swift, as I conceived in nearly two months. Before taking the pills, it did not work for over seven months. During pregnancy, folic acid is crucial for the development of the child, especially the brain and spinal cord. A deficiency can lead to severe consequences, including potential psychoses or mental retardation in the child.
9
Vital for fetal health
6 people found this helpful
Folic acid, part of the B-vitamin group, is crucial for DNA synthesis and cellular function. In early pregnancy, the fetus's organs, including the brain, develop quickly. Any defects during this critical period may lead to severe disabilities or death. Folic acid effectively reduces the risk of neural tube defects, making it essential for every woman, especially those who may become pregnant.
9
Increased energy
Great quality with top-notch ingredients! It's an easy-to-swallow size, and I feel it’s beneficial for my brain. I’ve noticed increased energy levels, improved potency, and a positive digestive response. It’s an excellent product from Iherb, and I will definitely purchase it again.
7.5
Family benefits
Accepted by the whole family, this quality folic acid has restored our damaged hair and nails, while also improving brain function. Our skin has become more elastic, and we feel generally better. The convenient once-a-day dosing has resulted in more energy and improved our nervous system health.
9
Prevents brain cancer
Folic acid restores immunity and supports heart function; it’s vital for expectant mothers and aids in cancer prevention while enhancing brain health. It plays a significant role in egg maturation, normalising the menstrual cycle, and fetal development. I recommend consuming 400-800 mcg daily.
7.5
Supports fetal health
5 people found this helpful
Its nutritional value is high and excellent for the price. I appreciated that the pill is small and easy to swallow. It is preferable to take it three months prior to pregnancy and continue through the early months as it enhances egg quality and protects the fetus, particularly the brain, from defects.
7.5
Prevents tumour growth
Folic acid is known for its excellent price and quality. The small, easy-to-swallow tablets play a vital role in many bodily processes, including cell growth and DNA integrity. A deficiency can lead to tumours, so it helps prevent neoplasms. It is also necessary for proper immune system function, cardiovascular health, and amino acid synthesis. Additionally, it benefits our nervous system, mood, and productivity, especially during pregnancy.
9
We explored an innovative treatment approach for glioblastoma multiforme by combining temozolomide and quercetin with folic acid-conjugated exosomes. The study showed that these exosomes enhanced drug delivery and penetration through the blood-brain barrier.
Our results indicated increased toxicity in brain tumor cells and a significant reduction in tumor size, indicating that this combination strategy could improve treatment outcomes. Through various experiments, we observed that folic acid's role in exosome uptake led to higher apoptosis rates in tumor cells, making this approach a promising avenue for glioblastoma therapy.
Our results indicated increased toxicity in brain tumor cells and a significant reduction in tumor size, indicating that this combination strategy could improve treatment outcomes. Through various experiments, we observed that folic acid's role in exosome uptake led to higher apoptosis rates in tumor cells, making this approach a promising avenue for glioblastoma therapy.
8
Folic acid enhances tumor treatment
We explored the effectiveness of folic acid-functionalized nanoparticles in improving the delivery and efficacy of doxorubicin against glioblastoma, a tough brain tumor. By specifically targeting cancer cells, this promising approach improved drug accumulation and resulted in better tumor cell apoptosis without causing liver damage.
Despite these advances, we found that while the nanoparticles showed great promise in therapy, the overall impact on survival time and body weight in animal models did not demonstrate significant benefits when considered alone. Thus, while this research is promising, more extensive studies will be needed to understand the full potential.
Despite these advances, we found that while the nanoparticles showed great promise in therapy, the overall impact on survival time and body weight in animal models did not demonstrate significant benefits when considered alone. Thus, while this research is promising, more extensive studies will be needed to understand the full potential.
7
Effective brain tumor delivery method
We evaluated a promising method for delivering treatments to brain tumors by using folic acid (FA)-conjugated brush polymers. This innovative approach was designed to cross the blood-brain barrier (BBB) effectively, targeting specific cells in the brain.
Our findings showed that these FA-brush polymers significantly accumulated in brain cell models, while non-FA versions did not perform well. This indicates that the polymers can transport therapeutic agents across the BBB and into glioma cells more efficiently.
Overall, these FA-modified polymers have strong potential for improving brain cancer treatment delivery.
Our findings showed that these FA-brush polymers significantly accumulated in brain cell models, while non-FA versions did not perform well. This indicates that the polymers can transport therapeutic agents across the BBB and into glioma cells more efficiently.
Overall, these FA-modified polymers have strong potential for improving brain cancer treatment delivery.
7
We explored how the proton-coupled folate transporter (PCFT) might help deliver drugs directly to glioma cells. By using imaging techniques and gene knockdown methods, we found that certain glioma cells take in folic acid-conjugated nanoparticles without affecting normal astrocytes.
The study showed that these glioma cells die when treated with nanoparticles that target PCFT. Interestingly, over a quarter of analyzed gliblastomas exhibited high levels of PCFT. Our findings suggest that targeting PCFT could be a promising strategy for developing new treatments for specific brain tumors.
The study showed that these glioma cells die when treated with nanoparticles that target PCFT. Interestingly, over a quarter of analyzed gliblastomas exhibited high levels of PCFT. Our findings suggest that targeting PCFT could be a promising strategy for developing new treatments for specific brain tumors.
References
- Pourmasoumi P, Abdouss M, Farhadi M, Jameie SB, Khonakdar HA. Co-delivery of temozolomide and quercetin with folic acid-conjugated exosomes in glioblastoma treatment. Nanomedicine (Lond). 2024;19:2271. doi:10.1080/17435889.2024.2395234
- Ali BH, Khoee S, Mafakheri F, Sadri E, Mahabadi VP, et al. Active targeted delivery of theranostic thermo/pH dual-responsive magnetic Janus nanoparticles functionalized with folic acid/fluorescein ligands for enhanced DOX combination therapy of rat glioblastoma. J Mater Chem B. 2024;12:5957. doi:10.1039/d3tb02429f
- Mazrad ZAI, Refaat A, Morrow JP, Voelcker NH, Nicolazzo JA, et al. Folic Acid-Conjugated Brush Polymers Show Enhanced Blood-Brain Barrier Crossing in Static and Dynamic Models Toward Brain Cancer Targeting Therapy. ACS Biomater Sci Eng. 2024;10:2894. doi:10.1021/acsbiomaterials.3c01650
- Liu HM, Zhang Y. Folic acid-decorated astrocytes-derived exosomes enhanced the effect of temozolomide against glioma. Kaohsiung J Med Sci. 2024;40:435. doi:10.1002/kjm2.12819
- Basso J, Mendes M, Silva J, Sereno J, Cova T, et al. Peptide-lipid nanoconstructs act site-specifically towards glioblastoma growth impairment. Eur J Pharm Biopharm. 2020;155:177. doi:10.1016/j.ejpb.2020.08.015
- Fukui N, Yawata T, Nakajo T, Kawanishi Y, Higashi Y, et al. Targeting CD146 using folic acid-conjugated nanoparticles and suppression of tumor growth in a mouse glioma model. J Neurosurg. 2021;134:1772. doi:10.3171/2020.4.JNS193078
- Kucheryavykh YV, Davila J, Ortiz-Rivera J, Inyushin M, Almodovar L, et al. Targeted Delivery of Nanoparticulate Cytochrome C into Glioma Cells Through the Proton-Coupled Folate Transporter. Biomolecules. 2019;9. doi:10.3390/biom9040154
- Farheen M, Akhter MH, Chitme H, Suliman M, Jaremko M, et al. Surface-Modified Biobased Polymeric Nanoparticles for Dual Delivery of Doxorubicin and Gefitinib in Glioma Cell Lines. ACS Omega. 2023;8:28165. doi:10.1021/acsomega.3c01375
- Miner MWG, Liljenbäck H, Virta J, Kärnä S, Viitanen R, et al. High folate receptor expression in gliomas can be detected using folate-based positron emission tomography with high tumor-to-brain uptake ratio divulging potential future targeting possibilities. Front Immunol. 2023;14:1145473. doi:10.3389/fimmu.2023.1145473
- Upadhaya P, Hazari PP, Mishra AK, Dutta B, Hassan P, et al. Radiolabelled folate micellar carriers as proposed diagnostic aid for CNS tumors by nasal route. Drug Deliv Transl Res. 2023;13:2604. doi:10.1007/s13346-023-01341-8
- Kamali M, Webster TJ, Amani A, Hadjighassem MR, Malekpour MR, et al. Effect of folate-targeted Erlotinib loaded human serum albumin nanoparticles on tumor size and survival rate in a rat model of glioblastoma. Life Sci. 2023;313:121248. doi:10.1016/j.lfs.2022.121248
- Martínez-Mendiola CA, Estrada JA, Zapi-Colín LÁ, Contreras-Chávez GG, Contreras I. Effect of pyridoxine or cobalamin supplementation on apoptosis and cell cycle progression in a human glioblastoma cell line. Int J Neurosci. 2024;134:1320. doi:10.1080/00207454.2023.2263815
